Molecular Link Found Between Prostate Cancer and Ewing’s Sarcoma, a Form of Bone Cancer

Molecular Link Found Between Prostate Cancer and Ewing’s Sarcoma, a Form of Bone Cancer
Proteins that contribute to the development of Ewing’s sarcoma, a form of bone cancer, also may play a role in prostate cancer, a new study suggests. The study, “An Interaction with Ewing’s Sarcoma Breakpoint Protein EWS Defines a Specific Oncogenic Mechanism of ETS Factors Rearranged in Prostate Cancer,” was published in the journal Cell Reports. Ewing's sarcoma is a rare bone cancer that affects one in one million children and young adults. The disease is very aggressive, and 44% of teens (aged 15-19) and 30% of children who develop it eventually die from it. This rare disease arises from errors in the process of chromosome (the structure in which DNA is organized within the nucleus of the cell) repair, allowing the merger of two separate gene segments into a mutant hybrid gene, known as a fusion gene. One of these genes is called EWS and the other is a gene that produces a group of proteins, called ETS. In the human body, 28 genes are responsible for the production of the ETS proteins. Among these genes, four - ETV1, ETV4, ETV5, and ERG - are known to cause prostate cancer. ERG alone has been associated with more than 50% of all prostate cancers; the other three genes have been implicated in about 7% of cases. Using mice and cultures of prostate cancer cells, researchers found that the four proteins produced by these four genes (and not proteins from the rest of the ETS group of proteins) were able to interact with the mutated and non-mutated EWS pro
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Joana brings more than 8 years of academic research and experience as well as Scientific writing and editing to her role as a Science and Research writer. She also served as a Postdoctoral Researcher at the Center for Neuroscience and Cell Biology in Coimbra, Portugal, where she also received her PhD in Health Science and Technologies, with a specialty in Molecular and Cellular Biology.

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