Spread of Prostate Cancer Cells to Bone Likely Caused by Enzyme, Mice Study Finds

Spread of Prostate Cancer Cells to Bone Likely Caused by Enzyme, Mice Study Finds
The MAOA enzyme, which is naturally occurring, is a major cause of the spread of prostate cancer cells to the bone, probably by triggering bone degradation, a study in mice found. Interestingly, an older generation anti-depressant was seen to slow the effect of the MAOA enzyme, disrupting the signaling that led to cancer cell invasion and proliferation. A researcher at Washington State University, Jason Wu, in collaboration with colleagues at Cedars-Sinai Medical Center and elsewhere, published the study, “MAOA-Dependent Activation of Shh-IL6-RANKL Signaling Network Promotes Prostate Cancer Metastasis by Engaging Tumor-Stromal Cell Interactions,” in the journal
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