Targeted Photodynamic Therapy May Help in Treatment of Prostate Cancer, Study Suggests

Targeted Photodynamic Therapy May Help in Treatment of Prostate Cancer, Study Suggests
Targeted photodynamic therapy may be a potential approach to treat prostate cancer, according to the results of a new preclinical study. The study, titled “Characterization of an In-111-labeled anti-PSMA antibody-photosensitizer conjugate for targeted photodynamic therapy of PSMA-expressing tumors,” was presented at this year’s Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging (SNMMI). Targeted photodynamic therapy is a technique that uses an antibody to target prostate cancer cells combined with specialized photosensitizers that tumor cells internalize. When the prostate is illuminated with light with a particular wavelength, tumor cells containing these molecules start dying. This method allows doctors to treat tumors with a minimally invasive procedure, while sparing nearby structures and their functions. In this study, researchers used an antibody targeting the PSMA protein, labeled with a radioactive tracer (indium-111), that allowed them to monitor which cells were being targeted. The photosensitizers were activated with a near-infrared (NIR) laser. The drug was called 111In-DTPA-D2B-IRDye700DX. "Coupling the photosensitizer to an imaging agent that targets PSMA on the tumor surface makes it possible to selectively and effectively destroy prostate tumor remnants and micrometastases while surrounding healthy tissues remain unaffected," Susanne Lütje, an MD and PhD and the study’s leading author, said in a news release. Researchers investigated the effectiveness and optimal
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