Obesity Makes Prostate Cancer Recurrence After Surgery More Likely, Study Reports

Obesity Makes Prostate Cancer Recurrence After Surgery More Likely, Study Reports
Prostate cancer recurrence after surgery is more frequent in men who are obese or have a metabolic syndrome, according to researchers. The results from the study, titled "Obesity and metabolic syndrome correlate with poor oncologic outcome in prostate cancer patients who underwent radical prostatectomy," were presented at the American Association for Cancer Research Special Conference Obesity and Cancer: Mechanisms Underlying Etiology and Outcomes, held Jan. 27-30 in Austin, Texas. Up to 30% of prostate cancer patients who undergo prostate removal (radical prostatectomy) eventually see their disease return. Until now, studies examining the association between body mass index (BMI) and metabolic syndrome with the risk of recurrence following radical prostatectomy have been controversial. A team from the Department of Urology at the Allegheny Health Network in Pittsburgh aimed to clarify the matter using a more comprehensive analysis. The study involved 1,100 patients who had undergone a radical prostatectomy at Allegheny General Hospital in Pittsburgh between 2003 and 2013. Researchers gathered data on patient prostate-specific antigen (PSA) levels, cancer staging and grading, recurrence time, and measures used to assess metabolic syndrome. A patient's prostate cancer was considered to have returned if he had two PSA measurements of over .2 nanograms per milliliter of blood. Metabolic syndrome is defined by the World Health Organization (WHO) as the presence of three of five f
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One comment

  1. Joe says:

    They also grouped men in the study as having “Low risk”, “Intermediate risk” and “High risk” Prostate Cancer but that important distinction is seemingly ignored in the report:

    “Among patients with a high BMI, the recurrence rate nearly doubled that of patients with a lower BMI – 32.4% versus compared to 16.9%. Those with metabolic syndrome had a four times greater chance of their cancer recurring than patients who did not.”

    How were these distributed among the three risk classes? Without breaking down the results for each of these classes the conclusions drawn are false and meaningless.

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