PSA Test in Asymptomatic Men Detects Low-risk Prostate Cancer but Doesn’t Save Lives, Trial Shows

PSA Test in Asymptomatic Men Detects Low-risk Prostate Cancer but Doesn’t Save Lives, Trial Shows
Using a single PSA test to screen men with no symptoms increases detection of low-risk prostate cancer, but does not reduce mortality, results from large U.K. clinical trial show. The study, “Effect of a Low-Intensity PSA-Based Screening Intervention on Prostate Cancer Mortality The CAP Randomized Clinical Trial,” was published in the Journal of the American Medical Association (JAMA). Prostate cancer is the second most common cause of cancer death in men from the U.S. and U.K., behind lung cancer. U.S. estimates for 2018 predict about 165,000 new cases and over 29,000 deaths from prostate cancer. The PSA test measures the blood levels of the PSA protein, which is often elevated in patients with prostate cancer. Although the test was initially approved in the U.S. to screen asymptomatic patients as well as to monitor disease progression, contradictory results from clinical trials led to different recommendations worldwide. Ongoing debate focuses on the trade-off between reduced mortality rates in patients who undergo screening and the potential harm from over-detection and over-treatment. Although detecting aggressive prostate cancer is crucial and needs to be done as early as possible, diagnosing harmless cancers severely impacts patients’ quality of life. These patients are at risk of infection following a biopsy, and may develop impotence
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José is a science news writer with a PhD in Neuroscience from Universidade of Porto, in Portugal. He has also studied Biochemistry at Universidade do Porto and was a postdoctoral associate at Weill Cornell Medicine, in New York, and at The University of Western Ontario in London, Ontario, Canada. His work has ranged from the association of central cardiovascular and pain control to the neurobiological basis of hypertension, and the molecular pathways driving Alzheimer’s disease.


  1. josep says:

    I have seen and read a lot about different breakthroughs yet I have not read about any new treatment.. I am really glad I don’t have prostate cancer but I had to deal with strong prostate symptoms that made me think I have it, after I got checked I was diagnosed with bph and got a treatment that helped me to get over it, the only “med” I take is a supplement named alpharise and it is very effective, what i like the most about it is that it has no side effects..the rest of my treatment is based on having a healthy alimentation and lifestyle. For a complete prostate support formula I use alpha rise and take extra magnesium with it too. Any other minerals I should take with it?

  2. josep says:

    I have tried many prostate supplements for my bph and some of them worked a better than others but definitely the best one I have tried is Alpharise. It has been the solution to my night problems

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