Long-term Use of Cholesterol-lowering Medications May Benefit Some Prostate Cancer Patients, Trial Shows

Long-term Use of Cholesterol-lowering Medications May Benefit Some Prostate Cancer Patients, Trial Shows
Long-term treatment with atorvastatin, a cholesterol-lowering medicine, may reduce the proliferation of prostate cancer cells in some patients, a randomized trial suggests. Results from the trial were published in the study, “Atorvastatin Versus Placebo for Prostate Cancer Before Radical Prostatectomy—A Randomized, Double-blind, Placebo-controlled Clinical Trial,” in the journal European Urology. Atorvastin is a type of statin, which is a medication that lowers cholesterol. The use of statins is associated with improved prostate cancer-specific survival, and laboratory studies have shown that statins exert numerous anticancer effects. However, they have never been tested in prostate cancer patients in a randomized clinical trial. To address this, researchers recruited 160 men with prostate cancer scheduled to undergo a prostatectomy at Tampere University Hospital in Finland to determine whether treatment with atorvastatin has any beneficial effects on prostate cancer, compared with a placebo. Patients were randomized to receive either 80 mg of atorvastatin or a placebo from the day they were enrolled in the trial until they had surgery. Participants received the treatment for a median of 27 days, with 96% compliance. Researchers evaluated a number of different parameters, including effect on tumor growth and levels of serum prostate-specific antigen (PSA) — a biomarker associated with prostate cance
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Iqra holds a MSc in Cellular and Molecular Medicine from the University of Ottawa in Ottawa, Canada. She also holds a BSc in Life Sciences from Queen’s University in Kingston, Canada. Currently, she is completing a PhD in Laboratory Medicine and Pathobiology from the University of Toronto in Toronto, Canada. Her research has ranged from across various disease areas including Alzheimer’s disease, myelodysplastic syndrome, bleeding disorders and rare pediatric brain tumors.

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