Surgery Plus Radiation Therapy Best at Extending Survival in Locally Advanced Prostate Cancer Patients, Study Says

Surgery Plus Radiation Therapy Best at Extending Survival in Locally Advanced Prostate Cancer Patients, Study Says
A combination of surgery and radiation therapy is better at extending the survival of men with locally advanced prostate cancer than radiation therapy plus hormone therapy, but is associated with higher rates of erectile dysfunction and urinary incontinence, a study found. These are the two combinations recommended for high-risk prostate cancer, but the study also shows that only 30 percent of men are getting them. The study, "Comparative Effectiveness of Radical Prostatectomy With Adjuvant Radiotherapy Versus Radiotherapy Plus Androgen Deprivation Therapy for Men With Advanced Prostate Cancer," was published in the journal Cancer. Despite increased screening availability, nearly one in 10 men will be diagnosed with locally advanced or regionally advanced prostate cancer, a kind of cancer that is growing but has not yet spread to other areas of the body. These men are at high risk for metastasis and current guidelines recommend they receive a combination treatment that includes either radical prostatectomy (surgical removal of the prostate) followed by radiation therapy, or radiation therapy plus androgen deprivation therapy (a treatment that reduces the levels of male hormones). But there is no consensus as to which approach is most effective. So, researchers reviewed the medical records of 13,856 men with locally advanced prostate cancer who were included in the Surveillance, Epidemiology, and End Results (SEER)–Medicare database from 1992 to 2009. Patients were 65 or older and were followed for a median of 14.6 years
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Inês holds a PhD in Biomedical Sciences from the University of Lisbon, Portugal, where she specialized in blood vessel biology, blood stem cells, and cancer. Before that, she studied Cell and Molecular Biology at Universidade Nova de Lisboa and worked as a research fellow at Faculdade de Ciências e Tecnologias and Instituto Gulbenkian de Ciência. Inês currently works as a Managing Science Editor, striving to deliver the latest scientific advances to patient communities in a clear and accurate manner.

One comment

  1. Harry Newman says:

    Yes, but EBRT plus brachytherapy boost (BBT) is superior to either RT plus ADT, and RP plus ADT.

    The article is misleading without stating the above.

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