Trial To Test Lynparza-Zytiga Combo Recruiting Men with Metastatic Castration-resistant Prostate Cancer

Trial To Test Lynparza-Zytiga Combo Recruiting Men with Metastatic Castration-resistant Prostate Cancer
A Phase 3 trial is recruiting men to test a combination of Lynparza (olaparib) and Zytiga (abiraterone acetate) for the treatment of metastatic castration-resistant prostate cancer (mCRPC). Named PROpel (NCT03732820), the trial was recently presented at the 2019 Genitourinary Cancers Symposium, in San Francisco, in a poster titled "PROPEL: A randomized, phase III trial evaluating the efficacy and safety of olaparib combined with abiraterone as first-line therapy in patients with metastatic castration-resistant prostate cancer (mCRPC)." Lynparza, jointly developed by AstraZeneca and Merck (MSD outside North America), is a treatment approved for some breast and ovarian cancers, and targets PARP proteins. By inhibiting these proteins, Lynparza (called olaparib, when used off-label) prevents cancer cells from repairing DNA errors, which eventually causes them to die. In a prior Phase 2 trial, a combination of olaparib plus the standard treatment of Zytiga and prednisone, given as second-line treatment, significantly delayed disease progression or death among mCRPC patients who h
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